Circulating Siderocytes in Human Subjects

Circulating siderocytes in human subjects.

By Doms Kuirni, A. DEIss AND C. E. C wrwmcrr T HE OCCURRENCE of siderocytes in the blood of splenectomized patients, in the blood of some patients with hemolytic anemia, and particularly in splenectomized patients with persistent hemolytic anemia is well known.’5 More recently, as a result of experimental studies in swine,6” it has been recognized that the physiologic significance and metabolic...

Experimental production of siderocytes.

Erythrocytes containing one or more granules that give a positive Prussian blue reaction for iron were apparently recognized by workers in the nineteenth century (1) but not until 1941 was the term "siderocyte" applied to them by Gruneberg (2, 3). The significance of siderocytes has been a matter of conjecture since their original description. Pappenheimer, Thompson, Parker, and Smith (4) sugge...

Cytological Studies on Siderocytes in Equine Infectious Anemia : I. Morphological Studies on Siderocytes

Gene expression of inflammatory molecules in circulating lymphocytes from arsenic-exposed human subjects.

Long-term arsenic exposure is associated with an increased risk of vascular diseases including ischemic heart disease, cerebrovascular disease, and carotid atherosclerosis. The pathogenic mechanisms of arsenic atherogenicity are not completely clear. A fundamental role for inflammation in atherosclerosis and its complications has become appreciated recently. To investigate molecular targets of ...

Clinical studies on the sites of production and clearance of circulating adrenomedullin in human subjects.

Adrenomedullin is a novel hypotensive peptide, newly discovered in pheochromocytoma. Because immunoreactive adrenomedullin is present in human plasma, adrenomedullin may play a role in regulating blood pressure. A recent report showed that human adrenomedullin mRNA is expressed not only in pheochromocytoma but also in the normal adrenal medulla, kidney, lung, and ventricle. However, whether or ...